My car is a 2013 V6 manual.

I was driving home from work on a highway onramp, in 3rd gear at around 3500rpm when the check engine light came on then flashed and the car lost power. I pulled over and it was idling rough. I shut it off and turned it back on, the check engine light was off and it was running normally.

I checked the codes and found the following:
P1450 - Unable to bleed up fuel tank vacuum
P0300 - Random misfire detected
P0301 - Cylinder 1 misfire detected
P0305 - Cylinder 5 misfire detected

I cleared the codes and went for a test drive. I drove similarly on another highway on ramp with the same results. Restarted and everything was back to normal.

On the way back home it happened again on a straight stretch while I was in 2nd at over 3000 rpm. This time after turning the car off and back on the check engine light was on constant. When I got home I checked the codes again and found the following:

P0301 - Cylinder 1 misfire detected
P0300 - Random misfire detected
P0305 - Cylinder 5 misfire detected

Are these related to any known issues? I'll probably take it in to the dealership but if I could have an idea what the problem might be heading in I'd feel better.

Thanks in advance.

 

Did your troubles start after getting gas?
Misfire on cylinder #1 and #5 Maybe bad gas or you need to change the spark plugs. You might have a bad coil or two also. Could be a vacuum leak too.
Search the internet, it will give you an idea on what's going on

 

The first time it occurred yesterday was before gas and the 2nd time was after.

I did a search online and found most of the possibilities you mentioned.

Also, I had the flywheel replaced in January due to a vibration. This same scenario occurred on one of my first drives after the flywheel was replaced. It was a nice, warm winter day so I was driving the car a little harder than I normally would during winter. Between then and yesterday I had been taking it easier on the car most of the time because of the weather.

A friend mentioned that there might have been a calibration or something related to the crank sensor that might need to be done or was done improperly when the flywheel was replaced. Is that possible?

 

I have an automatic but have read about you need to calibrate something when flywheels are replaced. I think your friend has you on the right track for the next thing you should check out.